Biggest Gainers on the NAS YTD 2025

June 29, 2025

Biggest Gainers

The biggest gainers in this list have seen their share price grow at a faster rate than the rest of the market so far this year. Stocks that are experiencing dramatic increases in share price can do so for a variety of reasons, including the sector they are in has turned (such as companies in the commodities space or a new sector that has huge future potential), the company is in talks to be taken over, or the company has restructured and earnings are turning better than expected.

NASDAQ

The National Association of Securities Dealers Automated Quotations (Nasdaq) located in New York City, is the most active stock exchange by volume in the United States.

About the Data

This table includes the top companies based on their percentage increase in share price year to date.

How do you use this table?

The biggest gainers are companies with upward momentum and potentially higher reward, but with increased risk. These stocks tend to have a higher trading volume and visibility in the marketplace. Stocks in this group can change direction quickly and tend to be short term trades. Stocks in this category are generally held for speculation or growth.

For an in-depth look at the fundamentals and valuation of each company, try the stockcalc platform free for 30 days.

SymbolNameTotal ReturnPeriod
RGC Regencell Bioscience Holdings Ltd 17653.04 YTD
DFDV DeFi Development Corp 2424.62 YTD
NAKA Kindly MD Inc 1722.58 YTD
ASST Asset Entities Inc 1329.15 YTD
TOI The Oncology Institute Inc 932.36 YTD
SBET SharpLink Gaming Inc 888.31 YTD
SVA Sinovac Biotech Ltd 850.08 YTD
NUTX Nutex Health Inc 429.06 YTD
TDUP ThredUp Inc 417.99 YTD
RGLS Regulus Therapeutics Inc 401.90 YTD
All data provided as at market close May 29, 2025.

Company Details

Regencell Bioscience Holdings Ltd

RGC:NAS

Total Return

17653.04

Period

YTD

Regencell Bioscience Holdings Ltd is a bioscience company focusing on the research, development, and commercialization of TCM for the treatment of neurocognitive disorders and degenerations, specifically ADHD and ASD, and infectious diseases affecting people's immune systems.

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DeFi Development Corp

DFDV:NAS

Total Return

2424.62

Period

YTD

DeFi Development Corp is an AI-powered online platform that connects the commercial real estate industry by providing data and software subscriptions as well as value-add services to multifamily and commercial property professionals.

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Kindly MD Inc

NAKA:NAS

Total Return

1722.58

Period

YTD

Kindly MD Inc is a holistically focused pain management clinic and healthcare data company. It offers direct health care to patients integrating prescription medicine and behavioral health services to reduce opioid use in the chronic pain patient population. Its specialty outpatient clinical services are offered on a subscription and fee-for-service basis to augment traditional healthcare.

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Asset Entities Inc

ASST:NAS

Total Return

1329.15

Period

YTD

Asset Entities Inc is an Internet company providing social media marketing, content delivery, and development and design services across Discord, TikTok, and other social media platforms.

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The Oncology Institute Inc

TOI:NAS

Total Return

932.36

Period

YTD

The Oncology Institute Inc offers oncology services committed to improving cancer prevention, diagnosis, treatment, research, and education. The company provides services including infusion centres. In-house dispensary, Outpatient blood transfusion, Outpatient stem cell transplant, financial counseling, clinical trials, comprehensive lab testing, and end-of-life counseling. The business operates in three operating segments dispensary, patients services and clinical trials and others.

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SBET:NAS

Total Return

888.31

Period

YTD

SharpLink Gaming Inc is a online technology company that connects sports fans, leagues and sports websites to relevant and timely sports betting content. The company owns a performance marketing platform through which the company owns and operates state-specific web domains designed to attract, acquire, and drive local sports betting and casino traffic directly to its sportsbook and casino partners which are licensed to operate in each respective state.

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Sinovac Biotech Ltd

SVA:NAS

Total Return

850.08

Period

YTD

Sinovac Biotech Ltd is a China-based biopharmaceutical company that focuses on research, development, manufacturing and commercialization of vaccines that protect against human infectious diseases including, without limitation, hepatitis A, hepatitis B, hand foot and mouth disease (HFMD) caused by EV71, seasonal influenza, H5N1 and H1N1 pandemic influenza, coronavirus, pneumococcus, poliomyelitis, varicella and mumps.

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Nutex Health Inc

NUTX:NAS

Total Return

429.06

Period

YTD

Nutex Health Inc is healthcare services and operations company with 20 hospital facilities in eight states (hospital division), and a primary care-centric, risk-bearing population health management division. The hospital division implements and operates healthcare models, including micro-hospitals, specialty hospitals and hospital outpatient departments (HOPDs).

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ThredUp Inc

TDUP:NAS

Total Return

417.99

Period

YTD

ThredUp Inc is an online resale platform for women and kids apparel, shoes, and accessories. It generates revenue from items that are sold to buyers through the website, mobile app and RaaS partners. Geographically, the majority of the company's revenue is generated from United States.

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Regulus Therapeutics Inc

RGLS:NAS

Total Return

401.90

Period

YTD

Regulus Therapeutics Inc is a biotechnology company focused on the development of microRNA therapies. MicroRNA therapies target diseases such as cancer, metabolic diseases, fibrosis, and inflammatory diseases. The product candidate of the company is RGLS8429, an anti-miR next-generation oligonucleotide targeting miR-17 for the treatment of autosomal dominant polycystic kidney disease (ADPKD), and is in Phase 1b clinical development.

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Regencell Bioscience and DeFi Development were the biggest gainers on the NAS YTD. See all the biggest gainers on the blog: https://www.stockcalc.com/Blog/biggest-gainers-nas-ytd-2025
Regencell Bioscience $RGC and DeFi Development $DFDV were the biggest gainers on the #NAS YTD. See the full list of gainers: https://www.stockcalc.com/Blog/biggest-gainers-nas-ytd-2025
Regencell Bioscience and DeFi Development were the biggest gainers on the NAS YTD. See all the biggest gainers on the blog: https://www.stockcalc.com/Blog/biggest-gainers-nas-ytd-2025

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